Capability Statement

GENOS LLC is a premier bioinformatics-as-a-service company, committed to enabling scientific teams with tailored bioinformatics capabilities and computational expertise. Our services span a spectrum of applications, enabling us to deliver innovative solutions that meet unique client needs.

* UEI, CAGE code, accepted payment methods, other federal contract vehicles, pertinent teaming agreements, etc.

Core Competencies

Past Performance on Services Offered

The current sole Founder of GENOS LLC, Dr. Osvaldo D. Rivera, and his related professional network, have a strong track record of delivering bioinformatics analyses for large-scale projects and contributing to peer-reviewed publications (ORCID, BeackonPR). Dr. Rivera has developed customized bioinformatics analyses and interactive reports complete with methodologies explanation, publication-ready figures and expert biological interpretation to guide follow-up experimental procedures.

GENOS aims to develop solutions that plug into existing workflows for biotech startups, so that we can focus on enhancing your R&D capabilities and accelerating product development timelines via high-quality bioinformatics services. Our successful delivery of bioinformatics-driven projects for academic institutions and private biotech companies (and soon healthcare organizations) establishes us as a trusted partner for biotechnological and biomedical organizations and research groups.

GENOS and its related service provider network have a track record of:

• Assisting clients in developing bioinformatics-driven research grant objectives through direct hands-on grant writing-revision support and strategic consulting.
• Developing customized genomics data production-level processing and analysis workflows for biotech startups, enhancing their R&D capabilities and accelerating their timelines.
• Delivering tailored molecular dynamics analyses of potential ligand-protein atomic interactions to academic investigators, contributing to the development of their biotech startup tech-transfer.
• Developing custom transcriptomic analysis pipelines for analysis of alternative RNA processing and editing, contributing to elucidating biology across human-derived tissue samples.
• Delivering standard genomic and transcriptomic analysis of cancer patient cohorts for collaborative academic projects, focusing on therapeutics development and populational genomics characterization, thereby contributing to mechanistic elucidation of disease.

Core Services

Genomic Data Analysis

Our genomic data analysis services encompass the entire spectrum of Next-Generation Sequencing (NGS) data, providing detailed insights through sophisticated bioinformatics techniques. All workflows include data processing, alignment, and reporting through our suite of integrative analyses.

• Variant Calling and Annotation: Identification and annotation of genomic variants, including SNPs, insertions/deletions (indels), and structural variants (SVs) from both DNA and RNA sequencing data. Our workflow includes standard quality control filtration and reporting, alignment to reference genomes, and functional impact prediction using gold-standard databases like dbSNP, ClinVar, and COSMIC.
• Transcriptome Profiling: RNA-Seq data processing and analysis including differential quantification of gene expression, modeling of alternative RNA processing, and discovery of isoforms from both short-read and long-read data. We leverage tools and methods for accurate gene transcript counting, normalization, probability estimation, and interactive gene structure modeling. Reports include integrative analyses of sequence regions of interest for gene regulatory patterns and mechanisms.
• Peak Calling: Peak calling statistics for nucleotide-protein interactions and binding sites from immunoprecipitation experiments (ChIP-seq, i/eCLIP, etc.), as well as DNA methylation patterns and histone modifications from bisulfite sequencing and chromatin accessibility assays (ATAC-Seq). Workflows include appropriate peak calling statistics and motif discovery tools.
• Genome Assembly: Construction and annotation of complete genomes from raw sequencing data through de novo assembly using standard assembler software. We provide statistics on scaffolding quality and confidence of assembly. Following assembly, we conduct genome annotation to identify genes, regulatory elements, and functional motifs. We also offer comparative genomics analysis to identify conserved regions, structural variants, and evolutionary relationships.
• Metagenomics Analysis (Coming Soon): Forthcoming metagenomics services will include sequence quality control, pre-processing, alignment, taxonomic classification using validated classifiers, and gene functional annotation. Services will encompass diversity and comparative analysis (e.g., alpha and beta diversity) for understanding complex microbial ecosystems.

Clinical Bioinformatics

Our clinical bioinformatics services leverage robust statistical techniques to transform clinical data into actionable insights, enabling precision medicine and personalized healthcare solutions. We integrate multi-omic datasets with clinical records to develop models that support prognosis, disease progression monitoring, and informed clinical decision-support.

• Outcomes Modeling: Predictive models for clinical outcomes using machine learning and statistical techniques. We integrate multi-omic data with clinical records to build models of prognosis, disease progression, and outcomes. We leverage genomics, transcriptomics, proteomics, and metabolomics datasets, along with cohort demographics and clinical histories, for decision support.
• Image Classification (Coming Soon): Deep learning algorithms to classify and analyze medical images, including CNNs and other ML techniques. The service will support various imaging modalities, including MRI, CT, X-rays, and histopathology slides.

Molecular Dynamics Analysis

Our protein modeling services offer a computational approach to understanding protein interactions. We provide insights into protein molecular dynamics, essential for drug discovery and understanding biological processes. For all workflows, we offer probability estimates based on the empirical distributions of macromolecular interactions. Post-analysis we leverage standard visualization tools and scripting for reporting on models.

• Protein-Protein Docking: We infer protein-protein and protein-ligand interfaces and binding affinities using standard three-dimensional docking tools. Our reports provide guided predictions for identifying potential drug targets. Our approach includes scoring functions to assess close-contacts, electrostatic interactions and solvation effects. We generate interaction maps and energy profiles for thermodynamic and kinetic aspects of binding.
• Molecular Dynamics Simulations: Detailed molecular dynamics simulations to capture the atomic behavior of proteins over time. Using industry-standard tools, we simulate conformational changes, flexibility, and stability of protein complexes. Deliverables provide temporal and spatial resolution of molecular movements for analysis of protein folding, binding kinetics, and allosteric regulation.
• Comparative Structural Analysis: We assess protein conformations to identify structural rearrangements and domain movements. We compare experimentally derived structures with simulated models, detect conformational shifts that influence protein function, and explore interaction complex capabilities. We model how mutations of interest or ligand binding events alter a protein's structure and infer changes to its interaction network.

Coming Soon: Proteomics and Metabolomics

Our proteomics services will offer detailed analysis of the proteome, leveraging advanced mass spectrometry (MS) techniques for high-resolution insights into protein expression, modifications, and interactions to support understanding cellular processes, identifying biomarkers, and developing targeted therapies.

• Standard Quantitative Proteome Profiling
• Protein Sequencing (QuantumSi) Analysis
• Post-Translational Modification (PTM) Analysis
• Protein-Protein Interaction Networks
• Biomarker Discovery
• Pathway Analysis

Key Differentiators

• Expert Leadership and Extensive Experience: Our network comprises highly skilled bioinformaticians with extensive experience across domains of bioinformatics and computational biology, enabling us to tackle complex challenges with confidence and precision.
• Innovative and Efficient Solutions: We leverage the latest technologies and methodologies to provide cutting-edge bioinformatics solutions. Our commitment to innovation ensures we deliver effective results, keeping clients at the forefront of scientific advancements, on time and within budget.
• Client-Centric Approach with Customized Services: We prioritize our clients' needs, tailoring our services to meet their specific research goals. We collaborate closely with clients to understand their unique requirements and provide personalized solutions.

NAICS Codes

Relevant PSC Codes

Employee Count: GENOS LLC operates as a sole member LLC with at least 2 other in-network bioinformatics scientists immediately available to provision contracts, ensuring personalized attention and direct involvement from the founder in all projects.

– Molecular Dynamics Client, UPR-RCM

"One of the best analyses that I've ever obtained from an external service provider [working with my data]."

Strategic location in Puerto Rico

GENOS is currently the only operational full-spectrum Bioinformatics-as-a-service (BaaS) brand in Puerto Rico. We have a commercial space co-location and SaaS partner agreement with local software corporation IT Group Technology Consultants Inc. GENOS LLC is a company formed in Puerto Rico and its business dealings may qualify other local corporations for Research Credits via Act60 incentive code. Additionally, GENOS LLC has participated in the BioLeap Accelerator Program's Inaugural Cohort and has the support of the Puerto Rico Science and Technology Research Trust. GENOS is a conceptualized brand, experimental business model, and incorporated organization actively being built by the Puerto Rico-based tech venture studio, Ozcorp Scientific.

GENOS is committed to advancing scientific projects via the provisioning of excellent bioinformatics services & innovative custom platforms. Partner with us to maximize the use of your biological data into actionable insights and drive your lab's or agency's research forward.

About GENOS: Website | LinkedIn. GENOS LLC (genos.bio) is a forward-thinking bioinformatics-as-a-service company enabling investigators to design and execute cutting-edge high-throughput data analyses without a significant investment in laboratory personnel, effectively reducing R&D bottlenecks and allowing the workforce to fully focus on executing assays and boosting revenue. GENOS is an organization conceptualized and actively being built by the Ozcorp Scientific biotech venture studio; for more information visit ozcorp.io/ventures.